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首页> 外文OA文献 >Complete DNA sequences of the mitochondrial genomes of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis: insight into the evolution of linear DNA genomes from mitochondrial telomere mutants
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Complete DNA sequences of the mitochondrial genomes of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis: insight into the evolution of linear DNA genomes from mitochondrial telomere mutants

机译：致病性酵母念珠菌和假丝酵母的线粒体基因组的完整DNA序列：线粒体端粒突变体线性DNA基因组进化的见解

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We determined complete mitochondrial DNA sequences of the two yeast species, Candida orthopsilosis and Candida metapsilosis, and compared them with the linear mitochondrial genome of their close relative, C.parapsilosis. Mitochondria of all the three species harbor compact genomes encoding the same set of genes arranged in the identical order. Differences in the length of these genomes result mainly from the presence/absence of introns. Multiple alterations were identified also in the sequences of the ribosomal and transfer RNAs, and proteins. However, the most striking feature of C.orthopsilosis and C.metapsilosis is the existence of strains differing in the molecular form of the mitochondrial genome (circular-mapping versus linear). Their analysis opens a unique window for understanding the role of mitochondrial telomeres in the stability and evolution of molecular architecture of the genome. Our results indicate that the circular-mapping mitochondrial genome derived from the linear form by intramolecular end-to-end fusions. Moreover, we suggest that the linear mitochondrial genome evolved from a circular-mapping form present in a common ancestor of the three species and, at the same time, the emergence of mitochondrial telomeres enabled the formation of linear monomeric DNA forms. In addition, comparison of isogenic C.metapsilosis strains differing in the form of the organellar genome suggests a possibility that, under some circumstances, the linearity and/or the presence of telomeres provide a competitive advantage over a circular-mapping mitochondrial genome.
机译：我们确定了两种酵母菌（假丝酵母和假丝酵母）的完整线粒体DNA序列，并将它们与它们近亲C.parapsilosis的线性线粒体基因组进行了比较。这三个物种的线粒体都具有紧凑的基因组，它们编码以相同顺序排列的同一组基因。这些基因组长度的差异主要是由于内含子的存在与否。在核糖体和转移RNA和蛋白质的序列中也鉴定出多种改变。但是，直立假单胞菌和金属隐孢子虫的最显着特征是存在线粒体基因组分子形式不同的菌株（圆形作图与线性作图）。他们的分析为了解线粒体端粒在基因组分子结构的稳定性和进化中的作用开辟了一个独特的窗口。我们的结果表明，通过分子内端对端融合从线性形式衍生出的圆形映射线粒体基因组。此外，我们建议线性线粒体基因组从存在于这三个物种的共同祖先中的圆形映射形式进化而来，同时，线粒体端粒的出现使线性单体DNA形式得以形成。此外，比较不同细胞器基因组形式的同基因异形梭菌菌株表明，在某些情况下，线性和/或端粒的存在提供了优于圆形作图线粒体基因组竞争优势的可能性。

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